Cryo-EM to understand molecular function

Abstract:

"Cryo-electron microscopy (cryo-EM) is a powerful technique for the structural analysis of samples that challenge other methods, such as large protein complexes involved in the regulation of gene expression, or cytoskeletal polymers engaged with associated factors. My lab has used cryo-EM to study both.Microtubules are essential cytoskeletal polymers that are regulated by a myriad of microtubule associated proteins (MAPs) and serve as freeways for motor proteins. Interestingly, there is a complex interplay between MAPs and motors on the microtubule surface.

We are characterizing the competition, coexistence, or regulatory interactions between these factors, with important repercussions for our understanding of microtubule-base cellular transport. Microtubules are also essential during cell division to form the spindle that segregates chromosomes between daughter cells. I will talk about kinetochore components that engage with microtubules for this function."

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